In this project we seek to better understand the factors underpinning the increasing prevalence of ticks and tick-borne disease by bringing together the observations and methodological tools of the natural and social sciences. Seeing natural and human systems as inherently intertwined, we call the focus our study the socionatural tick-borne disease nexus. We acknowledge that different landscapes provide more or less ideal environments for tick hosts and thus can increase the prevalence of ticks and tick-borne disease. However, we also recognize that the reasons for the increase in tick-borne diseases are complex and cannot be reliably explained or predicted by tick/host interactions and landscape models alone. We thus not only examine the links between land use change and tick-borne disease prevalence, but also the broad array of social mechanisms that contribute to the creation of landscapes where tick-borne disease can proliferate.